Young people recover quickly from rare side effect of Covid vaccine: study

According to a study, most young people under the age of 21 who develop suspected inflammation of the heart muscle linked to the COVID-19 vaccine, known as myocarditis, have mild symptoms that improve quickly. Myocarditis is a rare but serious disease that causes inflammation of the heart muscle. This can weaken the heart and affect the heart’s electrical system, which keeps the heart pumping regularly.

It’s most often the result of infection or inflammation caused by a virus, researchers say. The highest rates of myocarditis after COVID-19 vaccination have been reported in adolescent and young adult males, said Jane W Newburger, associate president at Boston Children’s Hospital and Commonwealth Professor of Pediatrics at Harvard Medical School , in the USA.

Although current data on symptoms, case severity and short-term outcomes are limited, we have set out to review a large group of suspected cases of this heart disease for the COVID-19 vaccine in adolescents. and adults under 21 in North America. said Newburger, lead author of the study. The study, published in the journal Circulation, examined the medical records of patients under the age of 21 using data from 26 pediatric medical centers in the United States and Canada. Canada.

Of the 139 adolescents and young adults, aged 12 to 20, the researchers identified and assessed most of the patients were white (66.2%), nine in 10 (90.6%) were male and the age median was 15.8 years. Almost all of the cases (97.8 percent) followed an mRNA vaccine, and 91.4 percent occurred after the second dose of the vaccine.

The onset of symptoms occurred an average of two days after the vaccine was administered. Chest pain was the most common symptom (99.3%), fever and shortness of breath occurred in 30.9% and 27.3% of patients, respectively.

About one in five patients (18.7%) was admitted to intensive care, but there were no deaths, the researchers said, adding that most of the patients had been hospitalized for two or three days. More than three-quarters (77.3%) of patients who had cardiac MRI scans showed signs of inflammation or damage to the heart muscle, they said.

Almost 18.7 percent had at least slightly decreased left ventricular function (compression of the heart) at presentation, but heart function returned to normal in all of those who returned for follow-up. “These data suggest that most cases of suspected COVID-19 vaccine-related myocarditis in people under the age of 21 are mild and resolve quickly,” said study lead author Dongngan T Truong, associate professor. at the University of Utah, United States.

“We were very happy to see this type of recovery. However, we are awaiting further studies to better understand the long-term outcomes of patients who have had myocarditis related to the COVID-19 vaccination,” Truong said. The researchers said future studies should follow patients who suffered from vaccine-associated myocarditis over a longer term, as this study only looked at the immediate course of patients and lacks follow-up data.

They also recognized several important limitations to consider. The study design did not allow scientists to estimate the percentage of those who received the vaccine and developed this rare complication, nor to examine the risk-benefit ratio.

Patients included in the study were also evaluated at academic medical centers and may have been more seriously ill than other cases found in a community.


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