What we know about causes, how often it happens and more – NBC Chicago

After several high-profile cases of “COVID rebound” in recent weeks, many Americans are curious about how common the disease is in patients who test positive for the virus.

Although not common, a return of COVID symptoms after an initial improvement could occur in up to 30% of cases, and in some cases a positive test result can occur even after multiple negative tests, as was the case for President Joe Biden in recent weeks.

Here is what we know about the phenomenon.

What is COVID rebound?

The CDC defines “COVID rebound” as occurring between “2 and 8 days after initial recovery, and is characterized by a recurrence of COVID-19 symptoms, or a new positive viral test after testing negative.”

How often does COVID rebound happen?

According to a new study published last week, COVID rebound occurred in about 27% of cases assessed by the project.

Of those cases, about 12% involved patients who tested negative for COVID and then achieved a viral load rebound sufficient to trigger another positive test.

The “pre-print study” (supposedly because it has not yet been published in a peer-reviewed journal) indicated a higher level of recurrence than some researchers expected, according to NBC News.

“It happens all the time. People who are not treated with COVID and then feel better may have symptoms afterwards,” Dr. Davey Smith of the University of California, San Diego said in a statement. .

Several high-profile examples of COVID rebounds have been reported in recent weeks. President Joe Biden, who tested positive for the virus earlier this year, had several days of negative tests before seeing a return of symptoms and then tested positive for the virus again.

He has since tested negative several days in a row and ended his isolation.

White House medical adviser Dr. Anthony Fauci also had a rebound case of COVID earlier this year.

Fauci and Biden were prescribed Paxlovid when they tested positive for the virus.

If you have been exposed to COVID or tested positive as the new BA.5 variant continues to spread in the United States and around the world, what should you do and have these guidelines changed?

What is Paxlovid?

Paxlovid is a COVID antiviral drug produced by Pfizer, and is primarily prescribed to COVID patients who are at risk of serious illness or hospitalization due to various pre-existing conditions and other factors, such as age and medical history.

The drug, which must be taken within five days of the onset of symptoms, has been shown in clinical studies to reduce the risk of hospitalization and death by 89%, officials said.

Does COVID Rebound mainly occur in patients who have taken Paxlovid?

According to several studies and government reports, a person could potentially experience a COVID rebound with or without taking the antiviral Paxlovid.

According to the CDC, rebound can occur “regardless of Paxlovid treatment and regardless of vaccination status.”

Although no large-scale studies have been done, it appears that people who were previously treated with Paxlovid show “mild illness” from their rebound cases, according to the CDC.

In response to the studies, the Food and Drug Administration asked Pfizer to test the effects of additional treatment of the antiviral in patients experiencing “rebound” cases. The data will be due by September 30 next year, according to the FDA.

What can cause a COVID rebound?

Researchers at the University of California, San Diego say one potential reason for a “rebound” in COVID symptoms is due to insufficient drug exposure, with insufficient drug reaching infected cells to prevent their replication to occur.

The study did not show any COVID-infected cells showing drug resistance in patients who had a rebound in symptoms, the doctors said.

What should you do if you experience a COVID rebound?

The CDC recommends that someone who has experienced a COVID rebound return to isolation for at least five days, or until their symptoms have improved, whichever is later.

Although the CDC does not recommend a second course of Paxlovid for patients who had already taken it, it may be prescribed in some cases, as was the case when Fauci saw a return of his COVID symptoms earlier this year.

The adviser told reporters his symptoms were more intense when he tested positive again and Paxlovid helped keep him out of hospital.

NBC Chicago

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