The forward, who has scored just one goal in his last eight appearances with the club, is carefully managed by his manager as the team’s only senior striker.
Goalkeeper Lukasz Fabianski was also left in London with Alphonse Areola having another chance to impress between the sticks as he looks to claim the No.1 spot.
Neither Antonio nor Fabianski have any injury concerns.
“We chose not to bring him,” Moyes said of Antonio.
“Other than that, only Lukasz is not here. You know where we are. We will be strong but we know we have big games to come and a very busy schedule.”
West Ham XI: areola; Coufal, Dawson, Diop, Masuaku; Noble, Soucek; Yarmolenko, Lanzini, Vlasic; Bowen
Subscribers: Randolph, Cresswell, Zouma, Johnson, Fredericks, Alese, Chesters, Kral, Rice, Benrahma, Fornals, Perkins
Dated: Thursday 25 November 2021. Kicks off at 5.45pm GMT, live on BT Sport 1.
West Ham team: Martin, Randolph, Areola, Diop, Dawson, Zouma, Baptise, Coufal, Johnson, Fredericks, Cresswell, Masuaku, Rice, Soucek, Noble, Kral, Vlasic, Yarmolenko, Fornals, Lanzini, Benrahma, Bowen.
rests: Fabianski, Antonio.