Ahead of Saturday’s trip to Leeds in the Premier League, Declan Rice, Tomas Soucek and Kurt Zouma are among the players expected to be resting for the third round game.
Captain Mark Noble is likely to get a rare start in midfield as he looks to put his dramatic penalty against United on Sunday behind him.
New signing Alex Kral is in line to make his debut, while next new boy Nikola Vlasic is also set to start.
Alphonse Areola should start in goal and Craig Dawson and Issa Diop should enter in the center.
Michail Antonio is available again after being suspended for Saturday’s 2-1 loss to United, but he’s unlikely to appear as Moyes manages his workload.
Scheduled lineup of West Ham (4-2-3-1): Areola; Fredericks, Dawson, Diop, Masuaku; Noble, Kral; Vlasic, Lanzini, Fornals; Yarmolenko.
West Ham team Areola, Randolph, Fredericks, Dawson, Diop, Masuaku, Johnson, Kral, Noble, Lanzini, Yarmolenko, Baptiste, Fabianski, Coufal, Zouma, Ogbonna, Cresswell, Rice, Soucek, Benrahma, Lanzini, Fornals, Bowen, Antonio.