The third-round clash pits one of the Premier League’s worst-performing sides against a Rovers side pushing for promotion out of the Championship.
This competition has never been won by double runners-up West Ham, despite reaching the quarter-finals in three of the last six seasons.
Jon Dahl Tomasson has promised to rotate his squad for the trip, which comes ahead of a huge local derby with promotion rivals Burnley this weekend.
Here are all the details…
Date, kick-off time and venue
West Ham vs Blackburn is set to kick off at 7.45pm GMT tonight, Wednesday 9th November 2022.
The London Stadium will host the game.
Where to watch West Ham v Blackburn
TV channel and live broadcast: The match will not be broadcast live on television in the UK.
West Ham vs Blackburn Team News
West Ham XI: Areola, Johnson, Aguerd, Ogbonna, Coufal, Coventry, Lanzini, Emerson Palmieri, Downes, Antonio, Fornals
Subs: Cresswell, Zouma, Scamacca, Dawson, Bowen, Benrahma, Soucek, Randolph, Hegyi
Blackburn XI: Pears, Rankin-Costello, Carter, Mola, Edun, Buckley, Adam Wharton, Markanday, Dack, Dolan, Vale
Subs: Kaminski, Hyam, Morton, Szmodics, Hirst, Brereton, Garrett, Phillips, Batty
West Ham vs Blackburn Prediction
Both teams are familiar with the midweek game grind, but the Hammers should have the quality in this one.
A 1-0 win at West Ham.
Head-to-head history and results (h2h)
The Rovers have beaten their opponents Wednesday night only once in more than 20 years.
West Ham win: 43
Blackburn win: 45
West Ham vs Blackburn match odds
West Ham: 1/3
Odds via Betfair (subject to change).