Wales suffered a 2-0 loss to Iran on Friday, leaving their last 16 World Cup hopes in tatters.
Goalkeeper Wayne Hennessey was sent off for serious misconduct as Wales were defeated by two goals in stoppage time.
Hennessey came out of his penalty area and took striker Mehdi Taremi out about 35 yards from goal with a high boot.
The Nottingham Forest goalkeeper initially took a booking for the challenge, much to the outrage of the Iranian team and fans at the stadium.
However, the referee then consulted VAR and opted to change the goalkeeper’s booking to a direct red card.
With Hennessey coming off the field, he was replaced in goal by Danny Ward with Aaron Ramsey, the Wales outfielder, to be substituted with just four minutes of regulation time remaining.
Wales appeared to have done enough to hold the draw, but Iran opened the scoring eight minutes into injury time.
A poor clearance from Joe Allen fell on substitute Roozbeh Cheshmi, who fired a shot from outside the box past Ward.
Iran then struck a second almost immediately as Rezaeian broke free and kept his composure to cut the ball over Ward.
Wales must now play England on Tuesday for a chance of qualifying for the knockout stages.