The first game is an early evening clash with the team tied on seven points with United at the top of Group F.
Villarreal suffered a last minute defeat in their second leg thanks to Cristiano Ronaldo and another win will put the Premier League side in the round of 16.
But Unai Emery’s side are on the verge of knockouts themselves and confidently dismissed Young Boys in their last European game.
Where to watch Villarreal vs. Manchester United
TV channel: The match will be televised on BT Sport 3, with coverage starting at 5:00 p.m. GMT. Kick-off is scheduled for 5.45 p.m.
Direct: UK viewers will be able to watch the match online through the BT Sport website or app.
You can also follow the action on Standard Sport with our LIVE Match Blog.