Antonio Conte has also confirmed he will be without an unnamed player who tested positive for Covid, while defender Japhet Tanganga is injured.
The question for Conte is whether to persist with his preferred 3-4-3 system or return to a five-man midfield or even a four-man full-back against the champions.
Assuming Conte persists with a back three, Dier should take Davinson Sanchez’s place which would allow Cristian Romero to move to the centre-right, bringing better balance to Conte’s defence.
Ryan Sessegnon, who was hooked after just half an hour of the dismal loss to Wolves last time out, is expected to keep his place in the squad, while January signing Dejan Kulusevski is pushing for a first start.
Emerson Royal and Matt Doherty are battling for the right-back spot, with neither having impressed recently.
Steven Bergwijn is available despite missing a few training sessions with a slight calf sprain this week.
Spurs predicted XI (3-5-2): Loris; Romero, Dier, Davies; Emerson, Hojbjerg, Bentancur, Winks, Sessegnon; Kane, son.
Or: Etihad Stadium, Manchester
When: Saturday February 19, 5:30 p.m.
TV: sky sports
Arbitrator: Anthony Taylor
Spurs squad from: Lloris, Gollini, Austin, Doherty, Emerson, Davies, Sessegnon, Dier, Romero, Sanchez, Rodon, Hojbjerg, Winks, White, Bentancur, Kulusevski, Lucas, Bergwijn, Son, Kane, Scarlett.
injured: Skipp (groin), Tanganga (knee)