The likely absence of Dejan Kulusesvki with a hamstring strain is a blow for Tottenham but spared Antonio Conte a tough decision on his front three for the decisive clash with Arsenal.
Heung-min Son, who scored a stunning hat-trick from the bench against Leicester last time out, will replace the Swede, likely forming an attack with Richarlison and Harry Kane.
Conte did not rule out a switch to 3-5-2 but favored a 3-4-3 system.
Ben Davies suffered a knee injury in the Champions League defeat to Sporting Lisbon and missed the Wales internationals. Clement Lenglet should therefore start on the left of the bottom three.
Conte has hinted at more opportunities for his summer signings – as well as Matt Doherty and Oliver Skipp – after the international break, but given the scale of the game the head coach is likely to stick with Emerson Royal at right-back, and a midfield two from Pierre-Emile Hojbjerg and Rodrigo Bentancur.
The only other question for the Spurs head coach is whether to play Ivan Perisic or Ryan Sessegnon at left-back, or even move Perisic to the right, as he did against Leicester.
The experienced Croatian can expect to get the nod from his favored side, not least because he’s such a threat to deliver from set pieces.
Conte confirmed some players had returned from international duty with ‘physical issues’ but pushed for more details, he said: “Honestly I don’t want to talk about the injury because I don’t want to give the advantage. at Arsenal.
“But of course we have to face problems, physical problems and we also have to know that we have just started playing the first game of a series that we have to play 13 days in 43 days.
“Of course we have to try to find the best solution and try not to take big risks because if we take big risks and lose players for the rest of the games it will be a disaster. I repeat to play all three days, I have to rely on the whole team and we try with the players to make the best decision as well.
Spurs predicted XI (3-4-3): Loris; Romero, Dier, Lenglet; Emerson, Hojbjerg, Bentancur, Perisic; Richarlison, Son, Kane.