Spurs traveled to Turf Moor on Wednesday morning for the fourth round clash with no England international due to be in the squad.
Winks has only started one league game this season and was substituted after an hour of 3-0 loss to Crystal Palace, while Dele started the campaign with a series of encouraging performances in a midfielder role deeper, but its shape has stabilized.
He was substituted at half-time in the North London derby loss to Arsenal, with Spurs down 3-0, and has not played a Premier League minute since.
Nuno admitted last week that Dele was “not having his best time”, but his latest omission casts further doubts over the 25-year-old’s future at the club.
Winks and Dele are desperate for regular first-team football and will likely consider their options in January if they continue to be ignored by Nuno.
Speaking in Arnhem, Winks admitted he had no idea how he went from England regular to disappointing for Tottenham’s second string and suggested Nuno’s decision to leave his first XI at home for the loss to Vitesse had an impact on morale.
When asked if he could make sense of his dramatic fall, Winks replied, “No, I can’t. But listen, the circumstances are I’m in this situation.
“Sure [my confidence is low]. When the players aren’t playing well and you have only you to blame, it’s hard. I want to be at my best, shoot and play really well. It comes with games. But at the end of the day, it comes with me on the pitch when I get the chance.
“If I don’t do that then I just have to blame myself. I’m man enough to admit that I need to improve in some areas. On the contrary, I need to play to games and the only way to [improve] gets minutes and gets that sharpness back. “
On Nuno’s rotation, he added: “We’re supposed to be a team. It’s supposed to be a competition. It’s supposed to be competitive. Everyone should be fighting for [a place in the] weekend games and it’s tough. “
Nuno is under pressure to get a result against the Clarets after his rotation policy backfired against Vitesse and West Ham, and he described the game as “a final” for Spurs.
“It will be a tough game as we hoped because Burnley are a good team but it’s a good chance for us to improve, knowing the Carabao Cup is an important competition for us,” he said. . “We have to go game by game and then this game is a final.”