However, as last week’s first leg showed, eliminating the Ligue 1 side will prove a difficult task – especially in their own backyard.
Tanguy Ndombele proved a threat at the London Stadium and scored the equalizer after Jarrod Bowen’s opener followed a red card for Aaron Cresswell.
A potential showdown with Barcelona awaits anyone who can seal their passage to the last four.
Here, Jack Rosser outlines the three key areas where West Ham must excel at Groupama Stadium…
England fans have rarely seen the best of Tanguy Ndombele, but the Tottenham loanee has offered a glimpse of what he can do in the first leg.
Tomas Soucek and Declan Rice struggled to control the midfield and he was allowed to dive deep, drive forward and dominate.
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West Ham may be new to this level, but there are a few who have been here before. Soucek and Vladimir Coufal have Champions League experience, as do Andriy Yarmolenko and Alphonse Areola.
After being pissed off last week, it’s crucial that West Ham keep their cool.
David Moyes has called his No.9 – and the striker needs to start delivering. Antonio can always cause trouble, but sometimes seems isolated.
The likes of Pablo Fornals and Jarrod Bowen need to be quick to get on and support their striker to get him fired.