They are two teams who know this competition well – Portugal won the inaugural Nations League in 2019, while local rivals Spain finished runners-up in the second edition two years later.
This time they are both in Group A2 with Switzerland and the Czech Republic as the sides face a turbulent four games in 10 days.
However, with a World Cup to come at the end of the year, every game is crucial as the teams look to ensure they finalize their preparations ahead of the trip to Qatar.
Date, kick-off time and venue
Spain v Portugal is set to kick off at 7.45pm BST tonight, Thursday June 2, 2022.
Estadio Benito Villamarin in Sevilla will host the game.
Where to watch Spain v Portugal
TV channel: Spain v Portugal will be shown live on Premier Sports 2. It currently costs £9.99 for a monthly subscription in the UK.
Direct: Premier Sports subscribers will also be able to watch the game online via Premier Player on mobile devices and tablets.
Live Blog: You can also follow all the action with updates from standard sports blog live tonight.
Spain vs Portugal Team News
David de Gea won’t feature after missing out on the Spain squad altogether – Brighton’s Robert Sanchez and Brentford’s David Raya were both favourites.
Aymeric Laporte withdrew from the squad last week with a knee problem, while Pedri is also injured. Alvaro Morata is expected to lead the line for the Spanish side.
For Portugal, there is no Ruben Dias in the squad as he continues his recovery from a hamstring injury.
Diogo Jota is set to feature less than a week after his involvement in Liverpool’s Champions League final loss to Real Madrid, while Cristiano Ronaldo is all but certain to make his 187th international appearance.
Prediction Spain vs Portugal
For two teams with so much attacking talent, recent encounters haven’t been particularly entertaining.
It’s been goalless the last two times the teams have faced each other, thinking there was that classic 3-3 draw at the 2018 World Cup.
With plenty of tired legs at the end of a long club season and the Nations League not a massive priority at this stage, it’s probably reasonable to expect a more low-key affair this time around.
Head-to-head history and results (h2)
Spain win: 17
Portugal wins: 6