Scoring four tries en route to a Six Nations title, Rees-Zammit was one of the stars of international rugby last year and was selected for the British and Irish Lions tour to South Africa.
But the 21-year-old had a slow start to the campaign and was exposed defensively by Darcy Graham in the win over Scotland. While Alex Cuthbert makes a solid return to Welsh colors and Josh Adams is expected to return from injury, Rees-Zammit has been dropped.
Premiership-based Wales players have to return to their clubs when not selected by the national team, so Rees-Zammit is expected to be included in Gloucester’s squad to face Leicester this weekend.
England and Wales will name their respective matchday 23 tomorrow.
Last night Eddie Jones reduced his squad to 25, with Joe Marchant and Joe Launchbury among the 10 players returning to their clubs for Premiership action this weekend.
That leaves the door open for Manu Tuilagi and Courtney Lawes to make their first league starts after overcoming injury.