Shakur Stevenson will run for a second division world championship when they face Jamel Herring in the early hours of October 24 in Atlanta, live on Sky Sports.
The undefeated and prodigious Stevenson will fight for the Herring Super Featherweight WBO title in a grudge match after months of back-and-forth talk.
Nico Ali Walsh, the grandson of Muhammad Ali, will be in his second professional fight on the undercard.
Ali Walsh impressively won his professional debut by knockout earlier this month.
Duke Ragan will also be in action for the first time since winning an Olympic silver medal. Troy Isley will also be in attendance.
But the evening will be hosted by Stevenson, a former featherweight world champion, considered one of the best talents in American boxing.
The 24-year-old is undefeated in his first 16 fights since winning an Olympic silver medal.
Herring, a former US Navy, is 11 years older, but in great shape.
In his most recent fight, Herring toppled and defeated Carl Frampton who subsequently retired.
“We are delighted to be back in Atlanta with a spectacular card featuring a super featherweight championship game between a veteran champion and one of the sport’s top young talents,” said Top Rank president, Bob Arum.
“And with names like Ali Walsh, Ragan and Isley on the undercard, big Atlanta fight fans will see many of the sport’s most promising youngsters.”
Herring said: “2021 has been good for me so far. I started the year with a big fight and a major win over Frampton.
“I can’t wait to end the year the same way I started it, not only with another huge win, but as the world champion. I have nothing more to say. focused on October 24 and the fourth title defense of my WBO belt. “
Stevenson said: “Jamel had to fight me or else he would have been stripped of his world title. I put him in a corner and I’m going to take his world title in a devastating way on October 24th.
“I can’t wait to fight in front of the amazing Atlanta fans. Believe me, you are going to see a show and I will become a two-weight world champion.”