Having won their group in the first leg of the competition, the Hammers face a daunting task against the club who have lifted this trophy more than any other.
David Moyes is taking his side to Spain after a narrow defeat at Liverpool, having been knocked out of the FA Cup days earlier.
Sevilla, meanwhile, have lost just one of their last nine but have become something of a draw specialist as their La Liga title battle with Real Madrid fades.
With kick off at 5.45pm GMT, here are the details to tune in…
Where to watch Sevilla vs West Ham
TV channel: The game will be shown live on BT Sport 3, with coverage starting at 5 p.m.
Direct: BT Sport subscribers will also be able to watch the action online via the BT Sport website or app.
Live Blog: Get minute-by-minute updates via Standard Sport’s dedicated match blog, with Spain’s Jack Rosser providing the expert analysis.