As Shields watched at ringside, Marshall was relaxed through the first two rounds as she fought her way through the fight.
But she showed more and more of her power and at the end of the third round she tagged Hermans with a stiff jab, before sending the Belgian crashing to the canvas with a devastating left hook.
The referee immediately left the fight, in the last second of the round, leaving Marshall heading for Shields after a decisive win that saw her defend her WBO middleweight title.
“It’s me and Claressa in the summer now,” Marshall said after the fight.
“I know Claressa can’t handle my power, I know when I land on her it’ll be a good night. I believe I hurt Claressa badly.
“It has to happen here in the Northeast.”
Shields replied, “As much power as she has, if that’s what I have to wait for, it’ll be annihilation.”
Promoter Ben Shalom has confirmed that the fight is potentially only days away from confirmation, and will likely take place even in late June or early June in England.
Marshall’s trainer Peter Fury said, “This is the biggest fight in women’s boxing, bar none.
“A powerful puncher against an excellent boxer. They are the two best and they have to face each other. Simple.”
Earlier in the night, Florian Marku defended his IBF International welterweight title with a fourth-round stoppage of Chris Jenkins.
The pair faced off in the third round which cut Marku, but roared by a large number of Albanian fans into the arena, he badly injured Jenkins in the fourth and the referee jumped up to wave him down. After the fight, Marku called out Amir Khan, Kell Brook and Conor Benn as he contemplated a huge fight this summer.
Zak Chelli earned a sixth-round stoppage on his return after a year out of the ring, against last-minute opponent Jack Kilgannon who didn’t take the fight until Thursday.
The super middleweight charged his shots throughout the fight and grew increasingly frustrated as the fight continued. Chelli’s mood was not helped when a clash of heads in round six opened a cut on his forehead, but with one second of the round remaining the fight was called off after Kilgannon was knocked down by a one -two punitive to the head. .
Brad Rea extended his unbeaten record to 13-0, comfortably beating Lukasz Ndafoluma with a 78-73 point decision in his favor.