Cox is expected to take the helm at the Twickenham Stoop on Saturday afternoon when the Harlequins meet Worcester in a two-team battle looking to build on impressive opening wins against Newcastle and London Irish respectively in 2021/22.
On Monday evening, Premiership Rugby posted on Twitter: “Kudos to @SaraCoxRef.
“She will become the first woman to referee a #GallagherPrem championship game on Saturday. Continually making history.
Saturday will be the last in a series of firsts for Cox, who last season became the first female assistant referee in Premiership history after working with Wayne Barnes and Christophe Ridley in the Wasps’ victory over Bath at The Rec.
She became the first female professional rugby union referee after being under contract with the Rugby Football Union (RFU) in 2016 and is also the first woman to officiate matches in the Premiership Rugby Cup, the English Championship and the League. national 1.