Saquon Barkley ruled out Thursday against San Francisco

New York Giants running back Saquon Barkley will not play against the San Francisco 49ers on Thursday night, the team announced.

Barkley injured his ankle late in the fourth quarter of New York’s win over Arizona and had to be helped off the field. He didn’t practice with the team this week, but Giants head coach Brian Daboll offered hope he might dress Thursday Tuesday, saying Barkley was “a quick healer.”

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And while that may be true, the team revealed that his ankle won’t be strong enough to support him for 60 minutes against San Francisco.

Matt Breida will likely slide into the starting role with Barkley sidelined, and he’s expected to share touches with Gary Brightwell and rookie Eric Gray. The team will also be missing starting left tackle Andrew Thomas.

Barkley has compiled 114 rushing yards this season, with a solo touchdown.

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Saquon Barkley