A Karim Benzema hat-trick secured Los Blancos a 3-1 aggregate lead from the first leg at Stamford Bridge, although the absence of the away goals rule diminishes that advantage somewhat compared to previous years.
Thomas Tuchel’s Chelsea bounced back at the weekend with demolition work against Southampton.
Meanwhile, Madrid went past Getafe at the Bernabeu – during which Gareth Bale was booed.
Here’s everything you need to know ahead of the game…
Date, kick-off time and venue
Real Madrid kick off against Chelsea is scheduled for 20:00 BST on Tuesday, April 12, 2022.
Madrid’s Estadio Santiago Bernabeu will host the match.
Where to watch Real Madrid vs Chelsea
TV channel: The match will be televised on BT Sport 2 and Ultimate, with coverage starting at 7 p.m.
Direct: BT Sport subscribers will be able to watch the match online via the BT Sport website or app.
Live Blog: You can follow all the action via Standard Sport’s live blog.
Real Madrid vs Chelsea team news
Eden Hazard (ankle), Isco (back) and Luka Jovic (muscle) all missed the first leg and are set to do so again this week, having missed the win over Getafe. Eder Militao is suspended.
Carlo Ancelotti has made some changes to his line-up for this game and is expected to recall Ferland Mendy, Luka Modric, Toni Kroos and Dani Carvajal to his line-up to face Chelsea.
The visitors are watching Romelu Lukaku after missing the trip to Southampton, which Hakim Ziyech benched for being a doubt.
Callum Hudson-Odoi (back) and Ben Chilwell (knee) are unavailable, with Timo Werner pushing for a start after a brace on the south coast.
Real Madrid vs Chelsea Prediction
Chelsea may well be on the verge of salvaging this tie, but it’s hard to see them keeping a clean sheet, with one goal enough to see Los Blancos through to the last four.
Chelsea win, 2-1.
Head-to-head history and results (h2h)
The first leg win was Real’s first against Les Bleus.
Real Madrid wins: 1
Chelsea win: 3