Ramos joined PSG on a free transfer from Real Madrid this summer, but a calf injury hampered the start of his career in the French capital.
The 35-year-old has not been in a competitive game since lining up for Real Madrid in last season’s Champions League semi-final second leg with Chelsea in May.
But his return to physical form is a boost for PSG head coach Mauricio Pochettino, who is taking an almost full squad to Manchester.
The star trio of Kylian Mbappe, Lionel Messi and Neymar all start at the Etihad.
PSG starting eleven: Navas, Hakimi, Marquinhos, Kimpembe, Nuno Mendes, Herrera, Paredes, Gueye, Messi, Mbappe, Neymar.
Subtitles: Ramos, Verratti, Icardi, Di Maria, Danilo Pereira, Dagba, Wijnaldum, Diallo, Kehrer, Ebimbe, Donnarumma, Franchi
wednesday 24 november 8 p.m. GMT
Arbitrator: Daniele Orsato (ITA)