Despite half a century of Moeen Ali, England missed six points in the chase as Pakistan took a 3-2 lead in the seven-game T20 series.
After batting Pakistan, England took regular wickets limiting the hosts to 145 runs.
In response, the Pakistani bowlers also took regular wickets as they managed to restrain and press the English batters.
Despite Moeen’s best efforts, Pakistan played well to win by five points, with debutant Aamir Jamal winning a brilliant final.
England needed 15 from the final but Jamal conceded seven points as Moeen couldn’t keep the yorker away.
Bad start costs England
England would have been confident they could chase the low total, but a combination of poor shot selection and good bowling early in the innings saw England fall behind the required rate.
Wood plays as England trouble Pakistan with short ball
Mark Wood was called back to the side after resting in the fourth T20 and his blistering pace again troubled the batsman, finishing with numbers 3-20.
Babar Azam, Haider Ali and Asif Ali all fell to Wood, who troubled Pakistan with his speed, accuracy and short ball.
Mohammad Rizwan is Pakistan’s top scorer, with 63, his fourth half in the series, after being dropped on 9 by Hales.
However, two outs and wickets by Wood, David Willey, Sam Curran and Chris Woakes prevented the innings from gaining momentum.
Woakes, who made his first international appearance since March, took the last wicket in the 19th.
Barber edged a bouncer from Wood in the third through the middle of the wicket, before Rizwan was dropped by Hales at nine.
But the bowler responded well, taking the wicket from Shan Masood, who shot poorly on a ramp and a thick edge took the ball in the air from Wood for an easy catch.
Wood was back in the attack in the eighth and almost immediately took a wicket, with Haider catching Wood easily.
Rizwan continued to score but England found little resistance at the other end.
Iftikhar Ahmed played well before cutting Willey on point and Asif Ali was knocked down by a swing leg yorker from Wood.
Two five-ball run-outs added misery for Pakistan, with England finishing the Pakistan innings with three wickets in 19th place.