Wednesday’s game is set to push Antonio Conte’s side to the limit once again after a somewhat improvised line-up was beaten by Liverpool at the weekend.
But Spurs have reached at least the last four in three of the last four seasons, with their 2008 final victory over Chelsea still infamously representing their most recent trophy.
Forest, meanwhile, have only reached the fourth round once in their last 17 attempts.
Here are all the details…
Date, kick-off time and venue
Nottingham Forest vs Tottenham is scheduled to kick off at 19:45 GMT on Wednesday 9 November 2022.
The City Ground will host the match.
Where to watch Nottingham Forest v Tottenham
TV channel and live broadcast: The match will not be broadcast live on television in the UK.
Live Blog: You can follow all the action via Standard Sport’s live blog.
Nottingham Forest vs Tottenham team news
Omar Richards, Harry Toffolo, Jack Colback, Giulian Biancone and Moussa Niakhate remain on Forest’s list of long-term absentees.
While battling relegation from the Premier League, it will be interesting to see just how well Steve Cooper rotates his roster.
Spurs could continue Dejan Kulusevski’s return from injury by starting the Swedish winger at the City Ground.
Heung-min Son, Cristian Romero and Richarlison are unavailable so Oliver Skipp, Fraser Forster, Bryan Gil and Pape Matar Sarr will be hoping for a chance to impress.
Nottingham Forest vs Tottenham Prediction
Both clubs can argue their focus is elsewhere, so the winner may be which manager puts his star players through their paces once again amid this busy run of games.
A 1-0 Spurs win.
Head-to-head history and results (h2h)
Ryan Mason and Roberto Soldado, along with a youngster Harry Kane, scored in Spurs’ 3-1 win in those sides’ September 2014 League Cup encounter.
Nottingham Forest wins: 36
Tottenham win: 56
Nottingham Forest vs Tottenham match odds
Nottingham Forest: 13/5
Odds via Betfair (subject to change).