Erik ten Hag has named his 22-man squad due to travel to Moldova today and the in-form striker did not take part in training on Wednesday morning.
Anthony Martial, Donny van de Beek and Aaron Wan-Bissaka are also out while there is a place for Luke Shaw, who recently returned from a foot injury.
Youngsters Alejandro Garnacho, Luke McNeil, Zidane Iqbal and Radek Vitek feature in the squad with Ten Hag capable of picking a stronger squad than expected given Premier League postponements either side of Thursday’s game.
United suffered defeat in their first group game last week, at home to Real Sociedad.
Full Man United Traveling Team:
GC: De Gea, Heaton, Vitek.
DEF: Lindelof, Maguire, Martinez, Malacia, Varane, Dalot, Shaw.
ENVIRONMENT: Fernandes, Eriksen, Fred, Casemiro, McTominay, Iqbal.
YOUR: Ronaldo, Antony, Sancho, Elanga, Garnacho, McNeill.