Erik ten Hag says the striker suffered from a minor illness while on the bench for the home draw against Newcastle, in which Cristiano Ronaldo was tasked with starting up front.
The scoreless outing should see Rashford return although Anthony Martial remains a major doubt after missing the game with a back injury so soon after overcoming an Achilles problem.
Christian Eriksen was also absent at Old Trafford but is potentially in line to return to the XI to face his former club.
Scott McTominay is available after serving a one-game suspension. Martin Dubravka also missed the Newcastle game while on loan from the Magpies and is eligible for the United squad again on Wednesday.
Harry Maguire will continue to miss as he nears a return to training. Axel Tuanzebe, Aaron Wan-Bissaka, Brandon Williams and Donny van de Beek are unavailable again.
Ten Hag will update fans on his team’s news at a press conference at 4 p.m. on Tuesday.
Predicts Manchester United XI: De Gea; Dalot, Varane, Martinez, Shaw; Casemiro, McTominay; Antoine, Fernandes, Sancho; Rashford.