Edinson Cavani (calf) is out but caretaker boss Ralf Rangnick says he is expected to return to training on Friday. Paul Pogba (calf) is also absent with full-back Aaron Wan-Bissaka a doubt with a kick.
United will also be without Fred tonight as the Brazilian midfielder is still struggling with the hip problem that ruled him out of the last three games.
Luke Shaw (ankle) and Harry Maguire (knee) are also unavailable and Jadon Sancho will miss the game after contracting tonsillitis.
Jesse Lingard and Marcus Rashford were unused substitutes against Arsenal on Saturday, although it remains to be seen whether Rangnick is ready to drop Cristiano Ronaldo or Bruno Fernandes.
Meanwhile, Diogo Dalot and Alex Telles are set to continue in wing-back roles for United against Chelsea.
Predicted Man United XI (4-2-3-1): De Gea; Dalot, Varane, Lindelof, Telles; McTominay, Matic; Elanga, Fernandes, Rashford; Ronaldo.