The Ukraine international was on the bench for Saturday’s Premier League win over Everton and will play his first game since his country was overrun by Russia.
Guardiola, speaking ahead of the trip to London Road, explained how good he thought playing for City would be for the 25-year-old.
“I think it will be good for him and to show that the reason he’s here is because he’s a magnificent player,” the City boss said.
Elsewhere, regular Cup goalkeeper Zack Steffen is still missing with a shoulder injury and the fact that young players such as Liam Delap, James McAtee and Kayky played in an Under-23 game on Monday evening means they are unlikely to feature.
Jack Grealish and Gabriel Jesus could also speed up their comebacks after coming off the bench at Goodison Park.
Manchester City predicted XI (4-3-3): Ederson; Walker, Ake, Stones, Zinchenko; Fernandinho, Gundogan, De Bruyne; Jesus, Foden, Grealish.
Hurt: Steffen (shoulder)
TV channel: ITV