The Premier League leaders emerged from a bruising Champions League encounter at Atletico Madrid on Wednesday with a place in the last four of that competition, but the run-in doesn’t stop until Saturday’s showdown with the Reds .
Kevin De Bruyne and Kyle Walker have both been sent off in the Spanish capital and are doubts for the game at Wembley.
“We have big problems,” Guardiola admitted after the game.
“We played three days ago, now we have a lot of injuries, I don’t know what will happen in the next few weeks.”
Nathan Ake has impressed as a makeshift left-back in recent weeks but could be brought back to centre, with Oleksandr Zinchenko also available.
Ruben Dias has been named to the bench for Atletico but a full return to the starting XI remains a question mark. Guardiola is likely to give Cup goalkeeper Zack Steffen a run between the posts.
Predicts Man City XI: Steffen; Cancelo, Stones, Laporte, Ake; Silva, Rodri, Gundogan; Mahrez, Sterling, Greish.