Pep Guardiola may decide to introduce a handful of young players into his starting line-up for the game, but the decision at the back has been made for him after Cancelo’s red card against Fulham.
A one-match ban will be served midweek, opening up a place for Sergio Gomez in the XI.
On the injury side, the visit from Chelsea should come too soon for Kyle Walker (groin) and Kalvin Phillips (shoulder).
Rico Lewis could replace Walker at right-back after scoring against Sevilla in the Champions League.
Cole Palmer and Josh Wilson-Esbrand, who both played in the third round of the Carabao Cup last season, are also in the running for a starting spot. Academy leading scorers Carlos Borges and Adedire Mebude are well placed to make the bench.
Guardiola, who faces the media to provide a squad update on Tuesday, is unlikely to make too many changes but Stefan Ortega is expected to start in goal.
Erling Haaland could be brought back into the line-up after scoring the late winner at the weekend following an ankle injury.
Predicts Manchester City XI: Ortega; Lewis, Dias, Laporte, Gomez; Palmer, Rodri, De Bruyne; Mahrez, Haaland, Foden.