The Spain international missed the draw with Everton due to a back problem.
This could mean Rico Lewis and Nathan Ake dropping out of the XI, with Riyad Mahrez and Jack Grealish also at risk of being dropped.
Only Ruben Dias is expected to miss the trip to London with a hamstring injury.
City could be boosted by the return of Julian Alvarez, who returned to training after the World Cup final and a long rest period. The striker is now back in training and offers another option for Guardiola.
Elsewhere, Phil Foden and Joao Cancelo could return to the squad, with City expected to put pressure on League leaders Arsenal.
Predicts Manchester City XI: Ederson; Walker, Stones, Laporte, Cancelo; De Bruyne, Rodri, Gundogan; Silva, Haaland, Foden.