Seven teams have booked their place in the quarter-finals, with Charlton being the only non-Premier League side among them, and whatever the result at the Etihad it will be a team with a strong history in the competition joining those already in the draw by lot.
Liverpool are the defending champions after beating Chelsea in the final last season, although a very different Reds side needed penalties to overtake Derby in the third round before the World Cup break.
Meanwhile, City won the Carabao Cup for four years on the rebound before that run was ended in the fourth round by West Ham last season.
Neither team will be full so soon after the World Cup, but it’s almost always entertaining when these two teams go head-to-head.
How to watch Manchester City vs Liverpool
TV channel: In the UK, the game will be shown live on Sky Sports Main Event and Football, with coverage starting at 7 p.m.
Direct: Fans can also watch the match live online via the Sky go app.
Live Blog: You can follow all the matchday action via Standard Sport’s live blog.