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Man who boosted his Pfizer COVID-19 vaccine with an injection of Moderna said his side effects were “a bit more severe” the third time around

From left to right: Joseph Hyser, study volunteer and virologist, Chanei Henry, principal research coordinator in molecular virology and microbiology, and Dr. Robert Atmar, principal investigator of the study. Baylor College of Medicine

  • Scientists in the United States are starting a booster trial, giving another vaccine to fully vaccinated people.

  • Participants receive a booster Moderna vaccine shot – whether they have already had 2 shots of one mRNA vaccine (from Pfizer or Moderna) or 1 adenovirus (J&J) shot.

  • One participant told Insider that her booster dose of Moderna gave her similar side effects to her second injection of Pfizer, but the third was “a bit more serious.”

  • See more stories on the Insider business page.

Virus expert Joseph Hyser has been fully vaccinated since late January, and he’s not really worried that his COVID-19 protection from the Pfizer vaccine has declined significantly since then.

Still, when he got an email last month asking if he’d be interested in a third booster dose – this time from Moderna – he didn’t hesitate to say yes.

The Baylor College of Medicine virologist immediately registered and took the elevator to the Baylor Vaccine Research Center, where he offered his arm for a third blow.

“Oooh I got boosted!” he recalled later boasting to family and friends, who were bewildered by his unique recall shooting experience.

Maybe they didn’t realize that Hyser is one of the first Americans to participate in a groundbreaking COVID-19 mix-and-match study, aimed at assessing whether boosters work and whether different COVID-19 vaccines are safe – and perhaps more effective – when mixed.

Although Hyser said he experienced “similar types of side effects” with both Moderna’s and Pfizer’s mRNA injections, he said the side effects were “a bit more evident with Moderna.”

Is it safe to mix snapshots from Moderna, Pfizer and Johnson & Johnson?

Man who boosted his Pfizer COVID-19 vaccine with an injection of Moderna said his side effects were “a bit more severe” the third time around

Dr. Robert Atmar is leading the booster dose study at Baylor College of Medicine in Texas. Baylor College of Medicine

This is not Hyser’s first vaccine trial, he has participated in studies of smallpox vaccines, anthrax vaccines, and annual influenza vaccines.

“I’m a nerd of wool, so I mean, sure, I think it’s interesting,” he said of the lawsuit. “I like to participate in the production of science and information for the world.”

The study he’s now a part of, funded by the National Institutes of Health, will evaluate the mix of different coronavirus booster vaccines to assess whether they will be safe and effective for adults of all ages in the United States.

For now, the study only stimulates with a single dose of Moderna’s vaccine, whether participants’ first vaccines were from Moderna, Pfizer, or Johnson & Johnson – the other two vaccines licensed in the United States. Other vaccine combinations and the order in which they are administered will be added to the study later.

Study participants will get routine blood drawn (Hyser has already had his first), and the first results could be ready in a few months.

A big question this study will explore is whether boosting people who received J & J’s single-injection adenoviral vaccine with Moderna’s mRNA vaccine could make performance similar. (J & J’s vaccine did not protect as well against mild and moderate disease as the two-dose mRNA regimens of Pfizer and Moderna during clinical trials.)

“Is it because of the [vaccine] build up, or is it because of the single dose? We don’t really have the answer to that, ”study principal investigator Dr. Robert Atmar of the Vaccine Research Center at Baylor told Insider of J & J’s weaker effectiveness.

A day of chills, body aches and ibuprofen after the 3rd dose

Man who boosted his Pfizer COVID-19 vaccine with an injection of Moderna said his side effects were “a bit more severe” the third time around

Chanei Henry, senior coordinator of molecular virology and microbiology research at Baylor College of Medicine, is preparing a COVID-19 vaccine. Baylor College of Medicine

While Hyser’s Moderna side effects were a bit more intense, he said they subsided with a little ibuprofen and a day off.

“I had, for Pfizer, a little chills, a little muscle aches, but nothing stopped me from carrying out my normal daily activities,” he said, recalling how, the day after his second shot in january, he did a little homework, went to the grocery store and made a pot of chili.

“With the recall it was a little more serious,” he said, describing waking up the next day feeling “like I had done a very rigorous gym workout,” with chills and chills. pain in his arms as if he had received a “hard blow to the shoulder.” He breathed ibuprofen, which helped relieve the pain, and the next day he felt himself again.

“Given the dramatic impact that [the coronavirus] has had around the world, as a scientist it’s actually very encouraging that these clinical trials are still going on and the secondary and tertiary questions are still being asked, ”Hyser said, estimating that he would make around $ 600 in the process. total (compensation for his time) during this study.

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