With goalkeeper Michael Carrick going undefeated in his three games in temporary charge before leaving somewhat surprisingly, Rangnick could make further progress as he pushes United to the top four with a win this afternoon.
He got rid of the blows received in the victory against Arsenal.
Elsewhere United remain without key center-back Raphael Varane, but his recovery from a thigh injury would go well.
Paul Pogba also stays on the sidelines, while Luke Shaw, Aaron Wan-Bissaka and Nemanja Matic all miss the starting lineup, as does Edinson Cavani, still injured.
Man United XI: De Gea, Dalot, Maguire, Lindelof, Telles, Fred, McTominay, Fernandes, Rashford, Sancho, Ronaldo
Subscribers: Henderson, Bailly, Jones, Wan-Bissaka, Elanga, Matic, van de Beek, Mata, Greenwood