The left-back arrived at City earlier this week on a four-year deal from Anderlecht, having impressed under former City captain and current Burnley manager Vincent Kompany.
Gomez is Oleksandar Zinchenko’s replacement and will compete with Joao Cancelo for a few minutes, the first of which could come at St James’ Park on Saturday night after Guardiola confirmed he would be traveling with the team.
“He’s ready,” Guardiola told reporters on Friday.
Providing an update on the rest of his squad, the boss added: “Cole [Palmer] is back, Kalvin [Phillips] is back. A few issues but all is well.
Erling Haaland failed against Bournemouth to add to his two goals scored against West Ham on the opening weekend, but Guardiola dismissed any early concerns.
“We are delighted with Erling,” he said. “It’s just a matter of time, making connections. Games, games, games.
Predicts Manchester City XI: Ederson, Walker, Dias, Ake, Cancelo; De Bruyne, Rodri, Gundogan; Mahrez, Haaland, Foden.