Phil Foden and Jack Grealish were given the nod against West Ham on the opening weekend and were effective without particularly standing out, although the latter fell to the bench.
Riyad Mahrez, who had only one minute of action at the London stadium, replaces Grealish.
Elsewhere, Bernardo Silva – who is a target for Barcelona – is absent as partners of Ilkay Gundogan, Kevin De Bruyne and Ikay Gundogan. Kalvin Phillips is unavailable, while Cole Palmer is doubtful.
Guardiola has an almost fully fit squad, with Aymeric Laporte his only other absentee. The defender is nursing the same injury that ruled him out of the US pre-season tour and is not expected to return until September.
Man City starting XI (4-3-3): Ederson; Walker, Dias, Stones, Cancelo; Gundogan, Rodri, De Bruyne; Foden, Haaland, Mahrez