Midfielder Thiago stopped with a hamstring problem during the warm-up ahead of the Carabao Cup final and missed both wins over Chelsea and Norwich as a result.
Centre-back Matip, who is suffering from a non-Covid-related illness, is also absent.
The Reds beat Norwich 2-1 on Wednesday to arrange a quarter-final trip to Nottingham Forest or Huddersfield but lost academy product Curtis Jones to injury during the match.
“Curtis Jones played a really good first half, we had to take him off because he felt his thigh slightly,” Klopp said. “I don’t think it was a real injury, but there was no need to take any risks and that’s why we brought Harvey [Elliott] to.”
The midfielder is only fit enough for a place on the bench, where he joins Diogo Jota as Luis Diaz is preferred alongside Mohamed Salah and Sadio Mane.
Starting XI: Alisson, Alexander-Arnold, Konaté, Van Dijk, Robertson, Fabinho, Keita, Henderson, Salah, Mane, Diaz.
submarines: Kelleher, Milner, Gomez, Oxlade-Chamberlain, Jones, Minamino, Jota, Origi, Elliott