Only a victory by four clear goals would put Liverpool back above Manchester City, but Klopp opted to rest the Premier League’s top scorer in Salah ahead of Saturday’s FA Cup final with Chelsea.
Robertson, meanwhile, gives up for Kostas Tsimikas.
Elsewhere, Roberto Firmino returns to the bench after his recent injury struggles.
Luis Diaz, Diogo Jota and Sadio Mane form the forward line, while Naby Keita and Curtis Jones sit alongside Fabinho in central midfield.
Joel Matip is chosen ahead of Ibrahima Konate as Klopp looks to balance a number of different competitions.
Anything other than a win at Villa Park would surely end any title hopes, although he couldn’t risk fatigue ahead of the FA Cup and Champions League final.
From Liverpool XI: Alisson; Alexandre-Arnold, Van Dijk, Matip, Tsimikas; Fabinho, Jones, Keita; Mane, Jota, Diaz.