A place in the quarter-finals is at stake and the Blues are in a strong position, thanks to a 2-0 victory at Stamford Bridge in the first leg of this round of 16.
Much has been said about the UK government’s restrictions on Chelsea’s spending on this trip to France and, amid the uncertainty off the pitch, Thomas Tuchel is hoping for a quiet night’s sleep there.
Owner Roman Abramovich was also sanctioned by the EU on Tuesday, but this game is still expected to go ahead as planned.
Lille are unbeaten without conceding since the first leg, while the Premier League side are on a four-game winning streak.
Here’s everything you need to know ahead of the game…
Date, kick-off time and venue
Lille vs Chelsea is set to kick off at 8pm GMT tonight, Wednesday 16th March 2022.
The Pierre Mauroy Stadium in Villeneuve-d’Ascq will host the match.
Where to watch Lille vs Chelsea
TV channel: Tonight’s game will be shown live on BT Sport 2 and Ultimate, with coverage starting at 7pm.
Direct: BT Sport subscribers will also be able to watch the action online via the BT Sport website or app.
Live Blog: You can follow all the action via Standard Sport’s live blog, with James Robson on the ground.
Lille vs Chelsea team news
The hosts are without Renato Sanches with a hamstring injury, after stopping in the weekend’s draw with Saint-Etienne.
Reece James is Chelsea’s big question mark after suffering another muscle injury last week. Ben Chilwell (knee) is out and Cesar Azpilicueta (illness) and Callum Hudson-Odoi (foot) are doubts.
Tuchel will have to decide if he is happy to risk resting in-form striker Kai Havertz, to give Romelu Lukaku another shot at the top.
Lille vs Chelsea Prediction
Chelsea are already halfway done and should be able to enjoy a relatively stress-free night in France.
Short of a big win against Clermont Foot, Lille have scored just one goal in four games and lack the European experience of their opponents’ big nights.
Chelsea win, 2-0.
Head-to-head history and results (h2h)
Lille win: 0
Chelsea win: 3