Kante has yet to recover from his knee twist, while Ben Chilwell (knee) Mateo Kovacic (hamstring) remains out.
Thomas Tuchel is grappling with a growing injury list, but the return of James, who missed the game midweek with a blow, is a boost.
Both Jorginho and Timo Werner were unused substitutes for the Vicarage Road game, with Tuchel opting to let the pair stand – who are in contention to start at the London Stadium.
Tuchel said: “I almost need a list [for how many players] did not train with Kovacic, N’Golo, Ben Chilwell and Trevoh Chalobah. They are all out for tomorrow. Everyone is available.
“Each player released is one player too many. There are a lot of midfielders [out]. For weeks we were without Kova and N’Golo.
“Ben Chilwell is long, we know that. For Trevoh, we need more exams to see how bad the injury is.