A win would send the Black Stars into the knockout stages and at least give revenge in the controversial World Cup quarter-final between the two nations in 2010.
Luis Suarez, always the villain of the pantomime, had a huge impact in this game and although Ghana have changed completely since then, it’s not hard to imagine this young team looking to right some wrongs.
Andre Ayew will almost certainly lead the line alongside Inaki Williams for Ghana, while Mohammed Kudus is establishing himself as one of the players of the tournament.
Left-back Gideon Mensah should be fit after replacing Baba Raham for the 3-2 win over South Korea earlier this week.
Suarez, meanwhile, could be called up against a country where one of the reporters called him ‘the devil’ during a press conference on Thursday.
Although ineffective against Korea, neither Edinson Cavani nor Darwin Nunez have impressed against Portugal and the Uruguayans need their talisman to lift their spirits after disappointing performances so far.
Barcelona defender Ronald Araujo is set to remain on the sidelines in another blow to La Celeste and manager Diego Alonso.
Ghana predicted XI: Ati-Zigi; Lamptey, Amartey, Salisu, Mensah; Partey, Abdul Samed; Kudus, A. Ayew, J. Ayew; williams
Uruguay predicted XI: Ratchet; Giminez, Coates, Godin; Varela, De Arrascaeta, Valverde, Bentanur, Nunez; Suarez, Cavani