A blistering start from Oxford blasted relegation-threatened Fleetwood before the visitors were forced to give up a 3-2 win.
Oxford took a two-goal lead in seven minutes to make it 3-0 inside 16 minutes, but a fightback from relegation-threatened Fleetwood at least provided a stunning finish.
Nathan Holland hit Oxford’s opener with less than two minutes left, hitting the bottom corner of Billy Bodin’s cross.
Cameron Brannagan doubled the play-off prospect’s lead in seven minutes, finding the same corner with a low drive after a nice one-two with Holland.
And on the quarter, Oxford were 3-0 up, as Bodin beat his man on the Brannagan cross and headed firmly inside.
Fleetwood finally started to show some life when Callum Camps hit the crossbar with a free kick and, six minutes before the break, referee Bobby Madley awarded them a penalty when Sam Long handled in the box.
Ellis Harrison fired the kick to offer the hosts hope.
That hope increased when Cian Hayes hit Fleetwood’s second in the 53rd minute, after Harrison’s challenge against U goalkeeper Jack Stevens forced the ball loose.
But, although they battled through the latter stages, they could not find the equalizer their second-half efforts warranted as they fell back into the relegation zone.