Lliot Daly will make his first appearance since the British and Irish Lions’ summer tour after being selected to start for the Saracens against the Chiefs of Exeter on Saturday.
Daly was injured for four months after sustaining a stress fracture in his leg, which required surgery, but is now ready to begin.
The England international will start on the wing and is one of three changes to the Saracens XV, with returning fullback Ben Earl and Alex Lewington also entering the side.
The London Irish are also in action on Saturday, when they host the Newcastle Falcons, and flanker Juan Martin Gonzalez is hoping to make his debut on the bench.
The Argentina international joined Irish in October and is now set to make his first appearance this weekend.
The Harlequins round out the weekend’s action by heading to Leicester Tigers, who currently lead the Premiership after winning all of their games so far this season.
Defending champions Quins, who are third, lost to the London Irish last week, their third loss of the campaign, and senior coach Tabai Matson is keen to bounce back quickly.
“There is now a long, uninterrupted period of games so hopefully we can start building that momentum again,” he said.