The Germans enter the first leg on a run of three consecutive draws, which included their successful navigation of their round of 16 against fellow Spanish side Real Betis.
Bundesliga clubs, namely Bayern Munich, have caused problems for Barcelona in recent years, resulting in three straight defeats against German sides.
But Xavi has given the Catalans hope so far by turning the Camp Nou ship around after a tumultuous period on and off the pitch.
Pedri struck a late winner against Sevilla at the weekend to put Barcelona second in the La Liga table, although their trophy hopes now hinge entirely on the Europa League.
Date, kick-off time and venue
Eintracht Frankfurt vs Barcelona is scheduled to kick off at 8pm BST on Thursday, April 7, 2022.
Deutsche Bank Park in Frankfurt will host the match.
Where to watch Eintracht Frankfurt vs FC Barcelona
TV channel: The match will be televised on BT Sport Extra 1.
Direct: BT Sport subscribers will be able to watch the match online via the BT Sport website or app.
Live Blog: You can follow all the action via Standard Sport’s live blog.
Eintracht Frankfurt vs FC Barcelona team news
Diant Ramaj (knee) misses for the hosts, who have doubts about Christopher Lenz (calf).
Dani Alves won’t take part in the competition for Barcelona as he wasn’t registered after returning to the club.
Samuel Umtiti (toe), Sergi Roberto and Ansu Fati (knee) are out while Sergino Dest (hamstring) is doubtful. Luuk de Jong missed the win over Sevilla with Covid and will therefore have to test negative to return.
Eintracht Frankfurt vs FC Barcelona Prediction
With Frankfurt recently becoming draw specialists and struggling to score, it’s hard to see this one being a classic.
Barcelona victory, 1-0.
Head-to-head history and results (h2h)
This is the first competitive meeting between the two teams.