It’s also unclear how long the protection from the first dose lasts without the boost from a second dose, Dr Fauci said during a White House press briefing in April.
“We have been concerned, and still are, that when you look at the level of protection after a dose, you can tell it’s 80 percent, but it’s a little tenuous 80 percent,” Dr. Fauci. He said it was concerning that more contagious variants that continue to spread around the world may partially escape the antibodies induced by the vaccine after a single dose. “You’re in a tight spot if you don’t have the full impact” of two doses, he said.
Although rupture infections after vaccination are rare, they do occur. A recent study of 250 people in Israel who were infected after being partially vaccinated with the Pfizer vaccine – between two weeks after the first dose and one week after the second dose – showed that they were disproportionately infected with B. 1.1.7, the variant first identified in Great Britain. The same study found that in a group of 149 people infected after the second dose of the vaccine, eight infections with B.1.351 (the variant first identified in South Africa) occurred between days seven and 13 after the second. dose. No rupture infection with the South African variant was observed 14 days after the second dose. Although this is a small sample, the finding suggests that full vaccination offers more protection against the variants, said Adi Stern, lead author of the study, professor at the Shmunis School of Biomedicine and Cancer Research. from Tel Aviv University.
Another study showing the benefits of a full vaccination looked at a group of 91,134 patients who had previously been seen by system physicians at the Houston Methodist Hospital and followed them between December and April. Most were not vaccinated, but 4.5 percent were partially immunized and 25.4 percent were fully immunized. There were 225 deaths from Covid-19 in the group, and 219 (97 percent) were among the unvaccinated. But five deaths (2.2 percent) occurred among those partially vaccinated. Only one person (0.004 percent) died in the fully immune group. In this study, full vaccination was 96 protective against hospitalization and 98.7% protective against death from Covid-19. But partially vaccinated people were only 77% protected against hospitalization and 64% protected against the deadly Covid-19.
Lead author of the study, Saad B. Omer, director of the Yale Institute for Global Health, said he started the research with a “neutral” view of the benefits of two doses over just one dose. But he is now convinced that the benefits of a second dose are significant.
“Based on the data from our study and other evidence, it doesn’t make sense for people to skip their second dose,” Dr. Omer said. “When it comes to preventing death with vaccines, the glass is 64% full, but wouldn’t you prefer it to be almost 100% full for an outcome as drastic and irreversible as death?”
Beyond the obvious health risks, skipping the second dose could also make your life difficult if you want to travel or visit establishments that require proof of vaccination. “You will not be considered fully vaccinated,” Dr Brownstein said. “It may have implications for getting back to normal. If your passport or vaccination card doesn’t show full status, there may be things that you won’t be able to do. You may not be able to get on an airplane. “