Chelsea suffered a double injury to put the brakes on an otherwise good night against Juventus.
Chilwell, meanwhile, was injured after an entanglement with Adrien Rabiot. The left-back slapped the turf with his hand and appeared to be in pain after injuring his knee.
Physios treated the player and took him away after helping him to his feet, with Cesar Azpilicueta in his place.
Chelsea led from the start of the showdown at the top of Group H via a Trevoh Chalobah explosion at close range.
Reece James scored his fifth goal of the campaign to make two after the break before Loftus-Cheek helped Callum Hudson-Odoi for 3-0.