The Portugal international tested positive for Covid-19 and so missed out on Saturday’s dramatic win over Tottenham.
In his absence, Paul Pogba was pushed further up the pitch against Spurs with the Frenchman, Jadon Sancho and Cristiano Ronaldo combining effectively.
Anthony Elanga scored what could be a crucial goal in the Spanish capital last month, latching on to a pass from Fernandes as United salvaged a result after a game in which they were heavily outplayed.
There is hope Scott McTominay will be fit after missing out on Spurs victory with a calf injury, while Luke Shaw was due to return to training on Monday after a recent positive Covid test.
David de Gea, meanwhile, reportedly gave a false positive ahead of Saturday’s win and could therefore feature.
“With Scotty, I hope (he’s in good shape) but he had muscle problems with his calf,” Rangnick said. “That’s why we decided not to play him (against Spurs) because Scotty is only of value if he can play at 100 per cent physical ability.
“Hopefully Luke will be back in training on Monday and Bruno we will have to wait and see until Tuesday. It will probably be a last minute race with him – due to COVID-19.
“We have to be careful with the COVID-19 tests. David (de Gea) was the same. Yesterday David was out, he wasn’t supposed to play but his first rapid test turned out to be wrong.”