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Atrial Fibrillation Is More Common and Dangerous Than Previously Thought

Recent UPMC research has shown that atrial fibrillation is more common and more severe in people younger than 65 than previously thought, leading to higher rates of serious complications and lower survival rates. lower, requiring further study to improve treatment options.

Atrial fibrillation (Afib), a common type of arrhythmia increasing in people younger than 65, is more dangerous in this increasingly younger population than previously thought, according to a new study recently published in Circulatory arrhythmia and electrophysiology and written by physician-scientists at the UPMC Heart and Vascular Institute.

The study, which is among the first to examine a large group of Afib patients younger than 65 in the United States, found that these younger patients were more likely to be hospitalized for heart failure, stroke or heart attack and had significantly higher rates of comorbidity. and mortality, compared to people of the same age and sex who do not have Afib.

“Cardilogists know that in people under 65, Afib is extremely rare and not harmful. But there’s really no data to support that,” said lead author Dr. Aditya Bhonsale, MD, MHS, a UPMC cardiac electrophysiologist in HVI’s division of cardiology and also an assistant professor of medicine at the University of Pittsburgh.

Research approach and patient data

“At UPMC, we have seen many more young patients with Afib in recent years and wanted to understand the actual clinical course of these individuals. As a payer-provider of patient records at more than 40 hospitals, UPMC was in a unique position to ask this question, which no one had been able to ask before,” Bhonsale added.

Drawing on electronic health records of 67,221 UPMC patients seeking care for Afib from 2010 to 2019, researchers found that more than a quarter of them (17,335) were younger than 65 , a stark contrast to the commonly estimated 2% prevalence. This high proportion likely reflects a growing burden of cardiovascular risk factors among younger Americans, Bhonsale said.

The UPMC team found that over the course of a decade, survival rates for people with arrhythmia were 1.3 to 1.5 times worse for men with Afib and 1.82 to 3.16 times worse for women, compared to patients of the same age who did not suffer from it. The patients studied also had high rates of

heart disease
Cardiovascular disease refers to a group of conditions that affect the heart and blood vessels, such as coronary heart disease, heart failure, arrhythmias and stroke. It is caused by a variety of factors, including lifestyle choices (such as smoking and poor diet), genetics, and underlying medical conditions (such as high blood pressure and diabetes). Cardiovascular disease is one of the leading causes of death worldwide, but it can often be prevented or managed through lifestyle changes, medications, and medical procedures such as bypass surgery and angioplasty.

” data-gt-translate-attributes=”({“attribute”:”data-cmtooltip”, “format”:”html”})” tabindex=”0″ role=”link”>cardiovascular disease Risk factors, including smoking, obesity, hypertension and sleep apnea, which contribute to damaging structural and electrical changes in the heart over time.

“We are optimistic that the data from this study will promote future research to evaluate optimal therapies for patients with Afib,” said lead author Sandeep Jain, MD, director of cardiac electrophysiology in the Division of Cardiology. of HVI and also professor of medicine at the University. from Pittsburgh.

Reference: “Mortality, hospitalization and cardiac interventions in patients with atrial fibrillation aged less than 65 years” by Aditya Bhonsale, Jianhui Zhu, Floyd Thoma, Steve Koscumb, Krishna Kancharla, Andrew Voigt, Jared Magnani, NA Estes, Samir Saba , Oscar Marroquin, Suresh Mulukutla and Sandeep Jain, April 22, 2024, Circulation: arrhythmia and electrophysiology.
DOI: 10.1161/CIRCEP.123.012143

Other authors of the study were Jianhui Zhu Ph.D., Floyd Thoma, Steve Koscumb, Krishna Kancharla, MD, Andrew Voigt, MD, Jared Magnani, MD, NA Estes, MD, Samir Saba, MD, Oscar Marroquin, MD , and Suresh Mulukutla, MD, all of UPMC.

News Source : scitechdaily.com
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