Smith Rowe missed last weekend’s win over Wolves through illness but is back available as the Gunners bid for a top-four finish in the hunt for Champions League qualification.
Takehiro Tomiyasu is doubtful due to his calf injury.
Arsenal boss Mikel Arteta faces a selection dilemma over whether to start Smith Rowe or Gabriel Martinelli on the left flank.
Smith Rowe scored in his last appearance, a 2-1 win over Brentford, and will hope to start at Vicarage Road.
With Tomiyasu struggling, Cedric Soares is set to start again at right-back.
“We are in the same place as last week, we still have a doubt about Tomiyasu but I think the rest is in the right place,” Arteta said.
Arsenal predicted XI: Ramsdale; Cedric, White, Gabriel, Tierney; Partey, Xhaka; Saka, Odegaard, Smith Rowe; Lacazette.
Dated: Sunday March 6, 2 p.m. GMT, Sky Sports
Location: Vicarage Road
Arbitrator: Craig Pawson
The Arsenal team of: Leno, Ramsdale, Okonkwo; Cedric, Gabriel, Holding, Tavares, Tierney, Tomiyasu, White; Elneny, Lokonga, Odegaard, Patino, Partey, Saka, Smith Rowe, Xhaka; Lacazette, Martinelli, Nketiah and Pepe.
Doubts: Tomiyasu (veal)