Arsenal XI vs Nottingham Forest: Predicted line-ups, confirmed squad news and latest Premier League injuries
William Saliba is still out with a back injury, while Gabriel Martinelli (ankle) and Oleksandr Zinchenko (calf) will also miss the remainder of the campaign.
In their absence, Jakub Kiwior, Leandro Trossard and Kieran Tierney are all set to enter the team.
“They (Martinelli and Zinchenko) are both out for the rest of the season,” Arteta said.
“Gabi is a pretty nasty injury, we have to assess next week how long he will be out for, but it will be weeks at least.
“With Alex it’s a calf problem and he won’t be available to play the next two games.”
Arsenal are set to miss out on Manchester City in the Premier League title race and Pep Guardiola’s side will be crowned champions if the Gunners lose on Saturday.
Big changes are unlikely to be made by Arteta, although the season is effectively over, although Thomas Partey could return to the squad.
Predicted Arsenal XI (4-3-3): Ramsdale; White, Saliba, Kiwior, Tierney; Odegaard, Jorginho, Vieira; Saka, Jesus, Trossard.
Friday 20:00 GMT, Sky Sports
Place: Selhurst Park
Arbitrator: Michael Olivier
The Arsenal team of: Huh, Ramsdale, Turner; Gabriel, Holding, Kiwior, Tierney, White; Odegaard, Partey, Saka, Smith Rowe, Trossard, Vieira, Xhaka; Jesus, Nelson and Nketiah.
Hurt: Elneny (knee), Martinelli (ankle), Saliba (back), Tomiyasu (knee), Zinchenko (calf)