Smith Rowe has been battling a groin problem and revealed earlier this week that he will likely miss tomorrow night’s curtain raiser at Selhurst Park.
Tierney, Tomiyasu and Vieira also struggled with injury issues and struggled for minutes in pre-season.
Asked about the fitness of the Arsenal quartet on Thursday, Arteta said: “Well, three out of four of them, they’ll probably be training this afternoon.
“If all goes well, they will be available for selection in the squad. Hopefully they will start to recover because they missed a lot of minutes and time in pre-season. They are really important players for us.
Pressed to clarify who of the four won’t be training, Arteta replied: “Good question! You’ll find out tomorrow.
Other than that, Arsenal have a healthy record and Gabriel Jesus, Oleksandr Zinchenko and William Saliba are all set to make their competitive debuts against Palace.
Predicted Arsenal XI (4-3-3): Ramsdale; White, Saliba, Gabriel, Zinchenko; Odegaard, Partey, Xhaka; Saka, Jesus, Martinelli.
Friday 8pm BST, Sky Sports
Venue: Selhurst Park
Arbitrator: Michael Olivier
The Arsenal team of: Huh, Ramsdale, Runarsson, Turner; Bellerin, Cédric, Gabriel, Holding, Mari, Saliba, Tierney, Tomiyasu, White, Zinchenko; Elneny, Lokonga, Maitland-Niles, Odegaard, Partey, Saka, Smith Rowe, Vieira, Xhaka; Jesus, Martinelli, Marquinhos, Nelson Nketiah and Pepe.
Doubts: Smith Rowe (groin), Vieira (foot), Tierney (knee), Tomiyasu (calf)