Health

Anti-aging elixirs could be hiding in a $1 diabetes pill or a mysterious chemical on Easter Island



From a $1 pill that treats diabetes to a mysterious chemical discovered on Easter Island, researchers are looking for ways to banish old age.

Many projects have focused on increasing the length of time a person is healthy, while others have offered hope of rejuvenating cells to make skin 30 years younger.

A promising anti-aging treatment could be a drug used in chemotherapy and a compound found in vegetables that allows mice to live longer, reduce the risk of disease and increase endurance.

Others have proposed stem cell injections to repair tissue, a pill that treats diabetes, and resetting certain body parts — among other things that could one day help humans maintain their youthful glow.

From drugs that kill “aged” cells in the human body to a mysterious chemical discovered on Easter Island, researchers are looking for ways to banish old age.

“There are so many promising areas in aging research that it’s difficult to determine which is most important,” Andrew Steele, author of Ageless: The New Science of Aging Without Aging, told DailyMail.com.

“There are many exciting ideas, from the drawing board to clinical trials.

“The key message though is that we simply need more funding for this science.” In the United States, about $1 per person per year goes to public funding for biological research into aging, even though age-related diseases like cancer and dementia causes 85 percent of deaths in the United States.

Drugs that kill aged cells

One of the most promising areas of anti-aging research is “senolytic” drugs that kill aged and senescent cells, Steele explained.

In the laboratory, mice given a senolytic cocktail of two compounds, dasatinib (a drug normally used in chemotherapy) and quercetin (a “flavonoid” present in fruits and vegetables), became “younger”.

In the laboratory, mice given a senolytic cocktail of two compounds, dasatinib (a drug normally used in chemotherapy) and quercetin (a “flavonoid” present in fruits and vegetables), became “younger”.
Mice with progeria were treated with gene therapy

“It was shown in the laboratory that administered mice made them biologically younger,” Steele explained.

“They lived longer, had less cancer and heart disease, could run farther and faster on a treadmill and, frankly, they looked just great: after a course of senolytics, they had better fur, skin plumper, etc.

“There are over two dozen companies right now trying to take this idea from one that works in mice to one that works in humans.” So watch this space! »

The “reset switch” for human cells

Altos Labs is backed by $3 billion in cash and is the largest biotech launch of all time, with 500 employees and top scientists paid $1 million a year.

It’s backed by investments from Jeff Bezos (Elon Musk joked on Twitter, “If it doesn’t work, he’ll sue!”) and aims to establish facilities in San Francisco and San Diego.

The California-based company focuses on cellular rejuvenation – finding a “reset switch” for human cells.

In research led by Wolf Reik, vice president of Altos Labs, researchers used genetic switches known as Yamanaka factors on skin cells from middle-aged people.

After the cells grew in a laboratory dish, they were found to be 25 to 30 years younger.

Steve Horvath of Altos Labs said this year: “Today we see, in some ways, that it might be possible to have interventions that extend our healthy years.

“Many people follow influencers on social media who give lifestyle advice, from intermittent fasting to certain exercise routines.

“You can gain five years or whatever the number is, but it won’t be 50. And many people just can’t exercise or follow a healthy lifestyle, for whatever reason, and would like to have medication to help them.”

Altos Labs’ research continues.

Stem cell injections

Many universities around the world are studying the effects of stem cells on aging, including China’s Sun Yat Sen University, the University of Tehran, and Harvard.

Stem cells are cells that can develop into many different types of cells in the body.

As we age, stem cells can repair tissues less well, which can lead to inflammation and also increase the risk of cancer.

Entrepreneur Bryan Johnson – who is spending millions in his quest to become ‘young’ again – was injected with healthy, youthful stem cells by Cellcolabs

Companies such as Cellcolabs already market injections of “young” stem cells to wealthy users.

Entrepreneur Bryan Johnson – who is spending millions in his quest to become “young” again – has been injected with young, healthy stem cells by Cellcolabs.

“I am now made of young Swedish bone marrow after receiving an infusion of 100 million mesenchymal stem cells,” he said.

The $1 anti-aging pill

A series of trials in people aged 65 to 79 aims to measure the anti-aging effects of a drug, metformin, used to treat diabetes for decades.

The TAME trial will involve more than 3,000 older people to test whether taking metformin delayed the onset of age-related chronic illnesses such as heart disease and dementia.

Metformin is already widely used for diabetes

Tests on mice showed that metformin increased lifespan and “lifespan” (the period of time the animals remain healthy).

Since then, trials have shown that people using metformin have a reduced risk of certain cancers, including blood cancers and gastrointestinal cancers.

Researchers are particularly excited about the fact that metformin is widely used and safe, and is already approved by the FDA for use in diabetes — and costs less than a dollar a day.

The Targeting Aging with Metformin (TAME) trial will follow thousands of patients for six years to monitor its effects.

Steven Austad, senior scientific advisor at the American Federation for Research on Aging, said: “I don’t know if metformin increases people’s lifespan, but the existing evidence suggests that it very well could be the case. »

The Easter Island drug

Among the most promising anti-aging treatments being studied is a chemical discovered 50 years ago on Easter Island.

Rapamycin, produced by soil bacteria on this remote Pacific island, inhibits signals linked to aging – and has been shown to increase lifespan by 20% in yeast, 19% in worms, 24% in flies and 60% in mice, according to La Lancette.

Rapamycin is native to Easter Island (photo)

Initially approved as an immunosuppressant for organ transplant patients, the drug is currently being tested in dogs, alongside research in humans.

The Dog Aging Project is currently running TRIAD (Test of Rapamycin in Aging Dogs) on pets to measure its anti-aging effects.

Dietary restriction and human cells

Following a low-calorie diet can extend lifespan, several trials have shown — and ongoing research at Penn State University could determine exactly how long.

Limiting calories by 20 to 60 percent has been shown to promote longer lives in many animals, according to previous research.

Andrew Steele is the author of Ageless

The research focused on telomeres, a region of DNA located at the ends of chromosomes.

During human life, each time a person’s cells replicate, some telomeres are lost as the chromosomes are copied into the new cell.

Once cells have replicated enough times, the protective telomere cap completely dissipates.

Lead author Waylon Hastings said there are many reasons why calorie restriction can extend human lifespan, and the topic is still under study.

“One of the main mechanisms by which life extends has to do with a cell’s metabolism,” Hastings explained.

When energy is consumed in a cell, the waste products from this process cause oxidative stress which can damage DNA and destroy the cell.

“When a person’s cells use less energy due to calorie restriction, there is less waste and the cell does not break down as quickly.”

The researchers aim to reassess their study group after 10 years to measure the impact of calorie restriction on human telomeres.

News Source : www.dailymail.co.uk
Gn Health

Back to top button